High dose level radiation therapy for local tumour control in esthesioneuroblastoma.

Abstract

Esthesioneuroblastoma is an uncommon tumour of neural crest origin arising in the nasal cavity. This paper is a retrospective review of 7 patients with esthesioneuroblastoma treated at a single institution from May 1974 to July 1990. 5 patients were treated with radiation therapy alone and 2 patients were irradiated after surgical resection. No local or regional occurrence was observed in any patient at 6 months, or at 1, 3, 6, 11.5 and 12 years following treatment. One patient died of intercurrent disease 6 years after radiation therapy. 2 patients died of disease, 1 of distant metastasis at 6 months and the other patient of meningeal carcinomatosis and distant metastases 1 year after treatment. One patient is alive with distant metastases 1 year after treatment. None of the patients experienced significant complications of irradiation. High-dose irradiation (60 Gy or more) alone or in combination with resection is an effective local treatment modality for esthesioneuroblastoma.

• Authors: F Guedea, E Van Limbergen, W Van den Bogaert
• Journal: European journal of cancer (Oxford, England : 1990) (Eur J Cancer) Vol. 30A Issue 12 Pg. 1757-60 ( 1994) ISSN: 0959-8049 [Print] England
• PMID: 7880600 (Publication Type: Journal Article)

Topics

• Adolescent
• Adult
• Aged
• Combined Modality Therapy
• Esthesioneuroblastoma, Olfactory (radiotherapy, secondary, surgery)
• Female
• Follow-Up Studies
• Humans
• Male
• Middle Aged
• Nasal Cavity
• Nose Neoplasms (radiotherapy, surgery)
• Radiotherapy Dosage
• Radiotherapy, High-Energy
• Retrospective Studies