Abstract | STUDY OBJECTIVE: To evaluate and compare the efficacy of various pretreatment agents to attenuate or prevent opioid-induced muscle rigidity using a well-established, previously described clinical protocol. DESIGN: Prospective, controlled, single-blind, partially randomized study. SETTING: Large medical center. PATIENTS: INTERVENTIONS: MEASUREMENTS AND MAIN RESULTS: Rigidity was assessed quantitatively by measuring the electromyographic activity of five muscle groups (biceps, intercostals, abdominals, quadriceps, and gastrocnemius). Rigidity also was rated qualitatively by attempts to initiate and maintain mask ventilation, attempts to flex an extremity, and the occurrence of myoclonic movements. Pretreatment with the two nondepolarizing muscle relaxants had no effect on the severe muscle rigidity produced by high-dose alfentanil. Whereas thiopental was only mildly effective, the benzodiazepines midazolam and diazepam significantly attenuated alfentanil rigidity (p < 0.05). CONCLUSION:
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Authors | T J Sanford Jr, M B Weinger, N T Smith, J L Benthuysen, N Head, H Silver, T A Blasco |
Journal | Journal of clinical anesthesia
(J Clin Anesth)
1994 Nov-Dec
Vol. 6
Issue 6
Pg. 473-80
ISSN: 0952-8180 [Print] United States |
PMID | 7880510
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Hypnotics and Sedatives
- Neuromuscular Nondepolarizing Agents
- Alfentanil
- Atracurium
- Thiopental
- Diazepam
- Midazolam
- metocurine
- Tubocurarine
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Topics |
- Abdominal Muscles
(drug effects)
- Alfentanil
(adverse effects, antagonists & inhibitors)
- Atracurium
(administration & dosage, pharmacology)
- Diazepam
(administration & dosage, pharmacology)
- Elective Surgical Procedures
- Electromyography
- Humans
- Hypnotics and Sedatives
(administration & dosage, pharmacology)
- Intercostal Muscles
(drug effects)
- Midazolam
(administration & dosage, pharmacology)
- Middle Aged
- Muscle Rigidity
(chemically induced, physiopathology, prevention & control)
- Muscle Tonus
(drug effects)
- Muscle, Skeletal
(drug effects)
- Neuromuscular Nondepolarizing Agents
(administration & dosage, pharmacology)
- Preanesthetic Medication
- Prospective Studies
- Single-Blind Method
- Thiopental
(administration & dosage, pharmacology)
- Tubocurarine
(administration & dosage, analogs & derivatives, pharmacology)
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