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[Neuroleptic catalepsy in rats is accompanied by activation of brain prolyl endopeptidase and is eliminated by inhibitors of this enzyme].

AuthorsV B Narkevich, G A Nazarova, N N Zolotov, V F Pozdnev, K S Raevskiĭ
JournalDoklady Akademii nauk (Dokl Akad Nauk) Vol. 339 Issue 5 Pg. 691-3 (Dec 1994) ISSN: 0869-5652 [Print] Russia (Federation)
Vernacular TitleNeĭrolepticheskaia katalepsiia u krys soprovozhdaetsia aktivatsieĭ proliléndopeptidazy mozga i ustraniaetsia ingibitorami étogo fermenta.
PMID7874014 (Publication Type: Journal Article)
Chemical References
  • Serine Proteinase Inhibitors
  • Trifluoperazine
  • Thiorphan
  • Serine Endopeptidases
  • Prolyl Oligopeptidases
  • Leucine
  • ubenimex
  • Haloperidol
Topics
  • Animals
  • Brain (drug effects, enzymology)
  • Catalepsy (chemically induced, drug therapy)
  • Enzyme Activation
  • Haloperidol (adverse effects)
  • Leucine (analogs & derivatives, therapeutic use)
  • Prolyl Oligopeptidases
  • Rats
  • Serine Endopeptidases (metabolism)
  • Serine Proteinase Inhibitors (therapeutic use)
  • Thiorphan (therapeutic use)
  • Trifluoperazine (adverse effects)

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