Abstract | OBJECTIVE:
Trauma to the peripheral nervous system is a well-recognized cause of dystonia and tremor, but peripherally induced parkinsonism has not previously been documented. We seek to characterize peripherally induced tremor and parkinsonism and propose possible mechanisms for this phenomenon. DESIGN: Review of records of patients evaluated in the Movement Disorders Clinic between 1977 and 1993. In addition to demographic and clinical information, the records were screened for any potential predisposing factors. PATIENTS: Twenty-eight patients in whom the onset of tremor, parkinsonism, or both was anatomically and temporally related to local injury. INTERVENTION: The type and site of injury were verified by history and examination of records whenever possible. Severity of tremor and parkinsonism was assessed by clinical rating scales. Three patients with tremor and parkinsonism had their striatal [18F]- fluorodopa uptake and raclopride binding measured with positron emission tomography. MAIN OUTCOME MEASURE: Response to conventional antitremor and antiparkinsonian medication was assessed by a clinical rating scale. RESULTS: CONCLUSION: Central reorganization in response to peripheral injury may give rise to a motor disturbance, including tremor and parkinsonism.
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Authors | F Cardoso, J Jankovic |
Journal | Archives of neurology
(Arch Neurol)
Vol. 52
Issue 3
Pg. 263-70
(Mar 1995)
ISSN: 0003-9942 [Print] United States |
PMID | 7872879
(Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Adult
- Arm Injuries
(complications)
- Female
- Humans
- Male
- Middle Aged
- Neck Injuries
- Parkinson Disease
(etiology)
- Peripheral Nerve Injuries
- Tooth Injuries
(complications)
- Tremor
(etiology)
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