Kabuki make-up syndrome associated with chronic idiopathic thrombocytopenic purpura.

Although susceptibility to infections in Kabuki make-up syndrome (KMS) has frequently been reported, there have been few immunological studies. We describe a 14 year old girl with KMS exhibiting chronic idiopathic thrombocytopenic purpura (chronic ITP), including immunological studies. Corticosteroid therapy was not effective therefore splenectomy was performed. The patient's platelet count increased transiently. Immunological studies revealed normal T cell functions and low serum immunoglobulin A (IgA) levels. Because of the abnormalities of B cell functions in chronic ITP and low serum IgA levels in our patient, we speculate that there may be some abnormalities of humoral immunity in KMS.
AuthorsT Watanabe, M Miyakawa, M Satoh, T Abe, Y Oda
JournalActa paediatrica Japonica; Overseas edition (Acta Paediatr Jpn) Vol. 36 Issue 6 Pg. 727-9 (Dec 1994) ISSN: 0374-5600 [Print] AUSTRALIA
PMID7871993 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Immunoglobulin G
  • Prednisolone
  • Adolescent
  • Antibody Formation
  • Female
  • Humans
  • Immune System Diseases (complications)
  • Immunoglobulin G (blood)
  • Prednisolone (administration & dosage, therapeutic use)
  • Purpura, Thrombocytopenic, Idiopathic (complications, diagnosis, drug therapy)
  • Syndrome

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: