Long-term remission of neutropenia in Felty's syndrome after a short GM-CSF treatment.

Abstract

We report a case of Felty's syndrome in which neutropenia was corrected by a short-term treatment with recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF, 5 micrograms/kg/day s.c. for 14 days). Absolute neutrophil counts rose from 0.1 to 2.2 x 10(9)/l and remained > 1.0 x 10(9)/l 8 weeks after discontinuation of the GM-CSF therapy. A flare-up of arthritis and a decrease in platelet counts were observed.

• Authors: J Pereira, E D Velloso, H A Loterio, I M Laurindo, D A Chamone
• Journal: Acta haematologica (Acta Haematol) Vol. 92 Issue 3 Pg. 154-6 ( 1994) ISSN: 0001-5792 [Print] Switzerland
• PMID: 7871957 (Publication Type: Case Reports, Journal Article, Review)

Chemical References

• Recombinant Proteins
• Granulocyte-Macrophage Colony-Stimulating Factor

Topics

• Adult
• Eosinophils (drug effects)
• Felty Syndrome (blood, complications, drug therapy)
• Female
• Granulocyte-Macrophage Colony-Stimulating Factor (administration & dosage)
• Humans
• Leukocyte Count (drug effects)
• Neutropenia (blood, drug therapy, etiology)
• Neutrophils (drug effects)
• Recombinant Proteins (administration & dosage)
• Remission Induction
• Time Factors