[Effects of chrysotile on the conformation of membrane protein and the antagonistic action of aluminum citrate].

Abstract

Effects of Mangai and Laiyuan chrysotile on the conformation of membrane protein and the antagonistic action of aluminum citrate to them were studied with circular dichroism. Results showed that these two kinds of chrysotile could significantly reduce the amount of alpha-helix in membrane protein of human erythrocytes in 20 minutes with a dose-dependent manner. Effect of Mangai chrysotile was stronger than that of Laiyuan one. It suggested the changes in the conformation of membrane protein were the key link in chrysotile-caused hemolysis. After treatment with aluminum citrate, these effects weakened. It provided important information for elucidating the mechanism of aluminum citrate in antagonism to cytotoxicity of chrysotile.

• Authors: W D Wu, S J Liu, H Yin
• Journal: Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] (Zhonghua Yu Fang Yi Xue Za Zhi) Vol. 28 Issue 6 Pg. 347-9 (Nov 1994) ISSN: 0253-9624 [Print] China
• PMID: 7867453 (Publication Type: English Abstract, Journal Article)

Chemical References

• Asbestos, Serpentine
• Citrates
• Membrane Proteins
• Citric Acid

Topics

• Asbestos, Serpentine (antagonists & inhibitors)
• Circular Dichroism
• Citrates (pharmacology)
• Citric Acid
• Erythrocyte Membrane (chemistry)
• Humans
• Membrane Proteins (chemistry, drug effects)
• Protein Structure, Secondary