[Two siblings with 2,8-dihydroxyadenine urolithiasis].

Abstract

We treated two children with 2,8-dihydroxyadenine urolithiasis for over 7 years. The male prepositus was admitted to the hospital because of anuria when he was 10 months old. Bilateral urinary stones had caused the anuria. The stones were 2,8-dihydroxyadenine and his APRT activity was low. He has been treated with about 5.0 mg/kg/day of allopurinol without purine diet restriction. His sister, 3 years old at that time, also was found to have a renal stone. She has been treated with about 3.3 mg/kg/day of allopurinol without restricting purine. The allopurinol therapy without purine-restriction resulted in normal growth of both children with neither the recurrence of stone nor renal impairment.

• Authors: T Kambayashi, T Nakanishi, K Suzuki, K Fujita, A Tajima, K Kawabe
• Journal: Hinyokika kiyo. Acta urologica Japonica (Hinyokika Kiyo) Vol. 40 Issue 12 Pg. 1097-101 (Dec 1994) ISSN: 0018-1994 [Print] Japan
• PMID: 7863862 (Publication Type: Case Reports, English Abstract, Journal Article, Review)

Chemical References

• 2,8-dihydroxyadenine
• Adenine Phosphoribosyltransferase
• Adenine

Topics

• Adenine (analogs & derivatives, analysis)
• Adenine Phosphoribosyltransferase (deficiency, genetics)
• Child, Preschool
• Family Health
• Female
• Humans
• Infant
• Male
• Urinary Calculi (chemistry, genetics)