Pulmonary effects of closure of patent ductus arteriosus in premature infants with severe respiratory distress syndrome.

Abstract

UNLABELLED:

The pulmonary effects of closure of a patent ductus arteriosus (PDA) were investigated in 11 premature infants with severe respiratory distress syndrome. Successful closure of a PDA did not improve the short-term severity of pulmonary disease (24 and 48 h after treatment) as judged by the arterial/alveolar oxygen tension ratio or the amount of ventilatory support. Also, pulmonary mechanics measured 24 h before, 24 and 48 h after treatment, were not statistically different.

CONCLUSION:

Infants with severe respiratory disease requiring high ventilation pressure and high oxygen concentration, where structural changes in the lungs are already established, will rarely show short-term improvement in pulmonary disease as a result of closure of a PDA. The overall clinical condition may, however, improve as a result of reduced cardiovascular strain. Earlier treatment of a PDA could reduce the ventilation period and the possible risk of developing chronic lung disease.

• Authors: T Farstad, D Bratlid
• Journal: European journal of pediatrics (Eur J Pediatr) Vol. 153 Issue 12 Pg. 903-5 (Dec 1994) ISSN: 0340-6199 [Print] Germany
• PMID: 7859794 (Publication Type: Journal Article)

Chemical References

• Oxygen

Topics

• Ductus Arteriosus, Patent (physiopathology, therapy)
• Humans
• Infant, Newborn
• Infant, Premature
• Lung Compliance
• Oxygen (blood)
• Respiratory Distress Syndrome, Newborn (etiology, physiopathology)
• Respiratory Function Tests