Abstract | UNLABELLED: We describe an 11-year-old girl who initially had mild hepatosplenomegaly and then presented with abnormal expansion of CD3-negative granular lymphocytes in peripheral blood and Epstein-Barr virus (EBV) genome in the DNA obtained from the peripheral blood mononuclear cells (PBMNC). After approximately 3 years, she developed oedema, ascites, marked hepatosplenomegaly, and pancytopenia, and showed both a profile of anti-EBV antibodies of reactivated infection and a high titre of anti-cytomegalovirus antibody. Although she was treated with antibiotics, ganciclovir, and prednisolone, she died of hepatic failure. CONCLUSION:
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Authors | Y Fukunaga, T Asano, J Takehana, K Ambo, K Matsuoka, M Yamamoto |
Journal | European journal of pediatrics
(Eur J Pediatr)
Vol. 153
Issue 12
Pg. 894-7
(Dec 1994)
ISSN: 0340-6199 [Print] Germany |
PMID | 7859792
(Publication Type: Case Reports, Journal Article)
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Chemical References |
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Topics |
- CD3 Complex
(immunology)
- Child
- Fatal Outcome
- Female
- Granulocytes
(immunology)
- Hepatomegaly
(etiology)
- Herpesvirus 4, Human
(immunology)
- Humans
- Lymphoproliferative Disorders
(complications, immunology)
- Splenomegaly
(etiology)
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