High expression level of alpha 6 integrin in human breast carcinoma is correlated with reduced survival.

We recently reported that alpha 6 integrin mediates experimental metastasis in mice by functioning in the adhesion of tumor cells to the vascular endothelium. In the current study, we investigated the expression of human alpha 6 integrin in invasive breast carcinomas of 119 women. In 50% of the tumors alpha 6 integrin was expressed in the majority of the cells, and this expression was correlated with reduced survival time. By contrast, the 24% of patients with breast tumors devoid of alpha 6 integrin expression all survived. The tumors were also evaluated for clinical risk factors including histological grading and steroid receptor level. The combination of these factors with alpha 6 integrin expression was superior in predicting overall survival than considering the other factors alone. The correlation with decreased survival time was consistent, regardless of whether the tumors expressed the alpha 6 integrin A or B forms, which differ in their cytoplasmic domain. On the basis of this pilot study we consider alpha 6 integrin expression to be a novel prognostic marker for human breast cancer.
AuthorsK Friedrichs, P Ruiz, F Franke, I Gille, H J Terpe, B A Imhof
JournalCancer research (Cancer Res) Vol. 55 Issue 4 Pg. 901-6 (Feb 15 1995) ISSN: 0008-5472 [Print] UNITED STATES
PMID7850807 (Publication Type: Journal Article)
Chemical References
  • Integrin alpha6
  • Integrins
  • Animals
  • Base Sequence
  • Breast (chemistry)
  • Breast Neoplasms (chemistry, mortality)
  • Female
  • Humans
  • Immunohistochemistry
  • Integrin alpha6
  • Integrins (analysis)
  • Isomerism
  • Molecular Sequence Data
  • Polymerase Chain Reaction
  • Predictive Value of Tests
  • Prognosis
  • Rats
  • Reference Values
  • Risk Factors
  • Survival Analysis

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