Thrombolysis in pulmonary embolism: an adolescent with protein S deficiency.

Abstract

Because of the low incidence of pulmonary embolism in children, the therapeutic approach is extrapolated from guidelines for adults. An adolescent boy with a massive pulmonary embolism associated with protein S deficiency was cared for successfully with intravenous thrombolytic therapy using 1.3 mg/kg of rt-PA with a 2-hour infusion time. In the absence of contraindications, most physicians consider using thrombolytic drugs in hemodynamically unstable patients who have a pulmonary embolism. A recent study described a subset of hemodynamically stable patients with right-ventricular dysfunction who also might benefit from thrombolytic therapy.

• Authors: T A Degan
• Journal: The Journal of the American Board of Family Practice (J Am Board Fam Pract) 1994 Nov-Dec Vol. 7 Issue 6 Pg. 523-5 ISSN: 0893-8652 [Print] United States
• PMID: 7847117 (Publication Type: Case Reports, Journal Article)

Chemical References

• Tissue Plasminogen Activator

Topics

• Adolescent
• Asthma
• Comorbidity
• Humans
• Infusions, Intravenous
• Male
• Protein S Deficiency (complications, diagnosis)
• Pulmonary Embolism (diagnosis, etiology, therapy)
• Thrombolytic Therapy
• Tissue Plasminogen Activator (administration & dosage, therapeutic use)