Abstract |
Middle cerebral artery (MCA) occlusion in rats induced c-fos and junB mRNA 4h later in all ipsilateral cortex outside the MCA distribution and in many subcortical structures: medial striatum; most of thalamus including medial and lateral geniculate nuclei: substantia nigra; and hippocampus. The N-methyl-D-aspartate ( NMDA) antagonist, MK-801 (4 mg/kg, i.p.) inhibited c-fos and junB mRNA induction in the cortex, striatum, thalamus, and hippocampus but not in the substantia nigra. These data show that c-fos and junB mRNA induction in cortex, striatum, thalamus, hippocampus involves the activation of NMDA receptors whereas different receptors must be implicated in the induction in substantia nigra.
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Authors | H Kinouchi, F R Sharp, P H Chan, S Mikawa, H Kamii, S Arai, T Yoshimoto |
Journal | Neuroscience letters
(Neurosci Lett)
Vol. 179
Issue 1-2
Pg. 111-4
(Sep 26 1994)
ISSN: 0304-3940 [Print] Ireland |
PMID | 7845604
(Publication Type: Journal Article)
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Chemical References |
- RNA, Messenger
- Dizocilpine Maleate
|
Topics |
- Animals
- Brain Chemistry
(drug effects)
- Brain Ischemia
(metabolism)
- Cerebral Arteries
(physiology)
- Cerebral Cortex
(drug effects, metabolism)
- Dizocilpine Maleate
(pharmacology)
- Gene Expression
(drug effects)
- Genes, Immediate-Early
(drug effects)
- Genes, fos
(drug effects)
- Genes, jun
(drug effects)
- Hippocampus
(drug effects, metabolism)
- Male
- RNA, Messenger
(biosynthesis)
- Rats
- Rats, Sprague-Dawley
- Substantia Nigra
(drug effects, metabolism)
- Thalamus
(drug effects, metabolism)
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