Experimental aspergillosis in guinea pigs: influence of itraconazole on fungaemia and invasive fungal growth.

The guinea pig model of experimental aspergillosis was used to evaluate the efficacy of itraconazole 2.5 and 5 mg kg-1 in preventing the invasive phase of the disease when animals were already loaded with Aspergillus conidia. Evaluations were made by recording the survival rates, culturing fragments of nine organs, examining seven organs by means of histochemistry and immunohistochemistry (mAb EB-A1 to Aspergillus galactomannan) and by serological titration of galactomannan. The data indicate that itraconazole is highly effective in preventing true invasive aspergillosis. Serological evaluations of antigenaemia suggest that low titres may only reflect fungaemia, while titres of 1:8 and above are suggestive of invasive disease.
AuthorsJ E Arrese, P Delvenne, J Van Cutsem, C Piérard-Franchimont, G E Piérard
JournalMycoses (Mycoses) 1994 Mar-Apr Vol. 37 Issue 3-4 Pg. 117-22 ISSN: 0933-7407 [Print] GERMANY
PMID7845416 (Publication Type: Journal Article)
Chemical References
  • Antigens, Fungal
  • Itraconazole
  • Administration, Oral
  • Animals
  • Antigens, Fungal (blood, drug effects)
  • Aspergillosis (drug therapy, microbiology, mortality, pathology)
  • Aspergillus fumigatus (drug effects, growth & development, isolation & purification)
  • Disease Models, Animal
  • Guinea Pigs
  • Itraconazole (administration & dosage, pharmacology)
  • Treatment Outcome

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