Electrical stimulation of the kindled hippocampus briefly increases extracellular dopamine in the nucleus accumbens.

Abstract

The effect of electrical stimulation of the dorsal hippocampus on accumbens dopamine release was examined. Stimulation of the kindled hippocampus that produced stage 3 seizures evoked a brief increase in extracellular DA and DOPAC levels in the contralateral nucleus accumbens. In contrast, similar stimulation early in the development of kindling producing a stage 1 seizure did not evoke this increase.

• Authors: R E Strecker, M E Moneta
• Journal: Neuroscience letters (Neurosci Lett) Vol. 176 Issue 2 Pg. 173-7 (Aug 01 1994) ISSN: 0304-3940 [Print] Ireland
• PMID: 7830940 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Dopamine

Topics

• Amygdala (physiology)
• Animals
• Dopamine (metabolism)
• Electric Stimulation
• Electroencephalography
• Exploratory Behavior (physiology)
• Extracellular Space (metabolism)
• Hippocampus (physiology)
• Kindling, Neurologic (physiology)
• Male
• Microdialysis
• Motor Activity (physiology)
• Nucleus Accumbens (metabolism)
• Rats
• Rats, Sprague-Dawley
• Seizures (metabolism)