Bronchocentric granulomatosis and central diabetes insipidus successfully treated with corticosteroids.

Abstract

Bronchocentric granulomatosis (BCG) is a rare chronic granulomatous lung disease that leads to destruction of the airway walls. It has been observed in association with various conditions, but never, so far, been reported to involve the central nervous system. We report a case of histologically confirmed pulmonary bronchocentric granulomatosis temporally associated with a partial central diabetes insipidus (CDI). Although the pathological basis of the posterior pituitary gland involvement was not ascertained, the temporal association of bronchocentric granulomatosis and central diabetes insipidus, as well as the fact that corticosteroid treatment provided stable remission of both conditions after a 10 month follow-up, strongly suggest that central diabetes insipidus was aetiologically related to bronchocentric granulomatosis in this patient.

• Authors: G P Rossi, E Pavan, M Chiesura-Corona, F Rea, A Poletti, A C Pessina
• Journal: The European respiratory journal (Eur Respir J) Vol. 7 Issue 10 Pg. 1893-8 (Oct 1994) ISSN: 0903-1936 [Print] England
• PMID: 7828701 (Publication Type: Case Reports, Journal Article)

Chemical References

• Prednisone

Topics

• Diabetes Insipidus (complications, diagnosis, drug therapy)
• Female
• Granuloma (complications, diagnosis, drug therapy)
• Humans
• Lung Diseases (complications, diagnosis, drug therapy)
• Middle Aged
• Prednisone (therapeutic use)