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Therapy-related acute myeloid leukaemia following immunosuppression with azathioprine for polymyositis.

Abstract
A 52-year-old man developed therapy-related acute myeloid leukemia (AML) following prolonged immunosuppression with azathioprine for polymyositis. Karyotypic analysis showed deletions of the short arm of chromosome 7 and the long arm of chromosome 5. The importance of recognizing this potential complication while treating benign rheumatological and immunological diseases with purine analogues like azathioprine is emphasized. Therapy-related AML is a poor prognostic group that does not respond favourably to standard induction therapy.
AuthorsK Krishnan, P Adams, S Silveira, S Sheldon, L Dabich
JournalClinical and laboratory haematology (Clin Lab Haematol) Vol. 16 Issue 3 Pg. 285-9 (Sep 1994) ISSN: 0141-9854 [Print] England
PMID7828416 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Azathioprine
Topics
  • Acute Disease
  • Azathioprine (adverse effects, therapeutic use)
  • Chromosome Deletion
  • Chromosomes, Human, Pair 5 (ultrastructure)
  • Chromosomes, Human, Pair 7 (ultrastructure)
  • Humans
  • Karyotyping
  • Leukemia, Myeloid (chemically induced, genetics)
  • Male
  • Middle Aged
  • Polymyositis (drug therapy)
  • Prognosis

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