Abstract |
A 52-year-old man developed therapy-related acute myeloid leukemia (AML) following prolonged immunosuppression with azathioprine for polymyositis. Karyotypic analysis showed deletions of the short arm of chromosome 7 and the long arm of chromosome 5. The importance of recognizing this potential complication while treating benign rheumatological and immunological diseases with purine analogues like azathioprine is emphasized. Therapy-related AML is a poor prognostic group that does not respond favourably to standard induction therapy.
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Authors | K Krishnan, P Adams, S Silveira, S Sheldon, L Dabich |
Journal | Clinical and laboratory haematology
(Clin Lab Haematol)
Vol. 16
Issue 3
Pg. 285-9
(Sep 1994)
ISSN: 0141-9854 [Print] England |
PMID | 7828416
(Publication Type: Case Reports, Journal Article)
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Chemical References |
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Topics |
- Acute Disease
- Azathioprine
(adverse effects, therapeutic use)
- Chromosome Deletion
- Chromosomes, Human, Pair 5
(ultrastructure)
- Chromosomes, Human, Pair 7
(ultrastructure)
- Humans
- Karyotyping
- Leukemia, Myeloid
(chemically induced, genetics)
- Male
- Middle Aged
- Polymyositis
(drug therapy)
- Prognosis
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