Abstract |
1) The imidazoline, moxonidine (MOX), injected icvt into the anterior lateral ventricle of NZW rabbits induced ocular hypotension (> 7.0 mmHg) that persisted for two hrs. 2) L-659, 066 injected i.v. or icvt inhibited MOX-induced ocular hypotension, significantly. 3) L-657, 743, injected icvt at 100-fold lower concentration than icvt L-659, 066, significantly inhibited MOX-induced ocular hypotension. 4) Alpha-2- adrenoceptors, located in the CNS, play a role in MOX-induced ocular hypotension, as evidenced by the ability of the relatively selective alpha-2 antagonists, L-659, 066 and L-657, 743 to inhibit icvt MOX-induced ocular hypotension.
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Authors | W R Campbell, D E Potter |
Journal | Progress in neuro-psychopharmacology & biological psychiatry
(Prog Neuropsychopharmacol Biol Psychiatry)
Vol. 18
Issue 6
Pg. 1051-61
(Oct 1994)
ISSN: 0278-5846 [Print] England |
PMID | 7824759
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Adrenergic alpha-2 Receptor Antagonists
- Adrenergic alpha-Antagonists
- Antidepressive Agents
- Imidazoles
- Quinolizines
- L 657743
- vatinoxan
- moxonidine
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Topics |
- Adrenergic alpha-2 Receptor Antagonists
- Adrenergic alpha-Antagonists
(administration & dosage, pharmacology)
- Animals
- Antidepressive Agents
(administration & dosage, antagonists & inhibitors, pharmacology)
- Imidazoles
(administration & dosage, antagonists & inhibitors, pharmacology)
- Injections, Intravenous
- Injections, Intraventricular
- Intraocular Pressure
(drug effects)
- Male
- Pupil
(drug effects)
- Quinolizines
(administration & dosage, pharmacology)
- Rabbits
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