This study was undertaken to assess the efficacy of a standard regime of high-dose systemic oral
corticosteroids in the management of
retinal vasculitis. The study was performed because the single most common reason for referral to our specialist clinic is the apparent failure of patients to respond to a course of systemic
steroids, which in most cases appeared to be due to an inadequate initial dose. A retrospective study of 29 patients (30 treatment episodes) with sight-threatening
retinal vasculitis managed initially with high-dose systemic
steroids was evaluated 1 year
after treatment. Patients included in the study all started treatment with > or = 1 mg/kg
prednisolone and remained on a high
steroid dose (> or = 40 mg
prednisolone) for at least 5 weeks. No patient was on any other
immunosuppressive agent at the start of the study. Therapeutic success for this regime, as judged by improvement in visual acuity, was 60%, improving to 77% with addition of other
immunosuppressive agents. Eight patients required additional immunosuppressives. Although documented side-effects of
steroids were common (50% of cases managed on
steroids alone), in only 5 patients were they therapeutically important. Twelve of the 22 patients managed on high-dose
steroids alone were off treatment at 12 months. There was no correlation at any stage between visual acuity, activity index or relapses and the final visual outcome at 12 months. Seven cases had a poor visual outcome and the causes for this included relapse in the twelfth month of follow-up, persistent cystoid macular oedema and
lens opacity.(ABSTRACT TRUNCATED AT 250 WORDS)