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Multiple myeloma after treatment of essential thrombocythemia.

Abstract
An 83-year-old black woman with previously diagnosed essential thrombocythemia was treated with thiotepa to control the excessive number of platelets. Approximately 10 years later, multiple myeloma developed. This appears to be the first case of multiple myeloma occurring after alkylating agent therapy for essential thrombocythemia. Although the mechanism of the development of multiple myeloma has yet to be defined, continuing progress in cell biology may prove a strong association between multiple myeloma and other hematologic malignancies.
AuthorsP M Arlen, G A Goldkland
JournalSouthern medical journal (South Med J) Vol. 88 Issue 1 Pg. 79-81 (Jan 1995) ISSN: 0038-4348 [Print] United States
PMID7817232 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Thiotepa
Topics
  • Aged
  • Aged, 80 and over
  • Female
  • Humans
  • Multiple Myeloma (chemically induced)
  • Thiotepa (adverse effects, therapeutic use)
  • Thrombocytosis (drug therapy)

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