Abstract |
BR-16A is an herbal (non allopathic) medication used in India to enhance cognition. In experiment 1, 28 Wistar rats received either BR-16A (200 mg/kg/day) or vehicle alone for 3 weeks. During the third week, the rats were tested for learning in the Hebb Williams complex maze. BR-16A-treated rats showed significantly better learning than did controls. Experiment 2 was conducted identically except that during the second week all of 32 rats additionally received six once-daily electroconvulsive shocks (ECS). An advantage for learning was again demonstrated for the BR-16A group. It is concluded that BR-16A facilitates learning, and that this effect extends to a protection against ECS-induced anterograde amnesia. Cognitive deficits induced by electroconvulsive therapy are a major disadvantage of the treatment and, to-date, no drug has been found to offer satisfactory protection against such deficits. It is suggested that BR-16A may hold promise in the containment of electroconvulsive therapy (ECT)-induced cognitive compromise.
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Authors | J Joseph, B V Venkataraman, M A Rani, C Andrade |
Journal | Biological psychiatry
(Biol Psychiatry)
Vol. 36
Issue 7
Pg. 478-81
(Oct 01 1994)
ISSN: 0006-3223 [Print] United States |
PMID | 7811845
(Publication Type: Journal Article)
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Chemical References |
- Mentat
- Plant Extracts
- Psychotropic Drugs
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Topics |
- Amnesia
(etiology, physiopathology, prevention & control)
- Analysis of Variance
- Animals
- Disease Models, Animal
- Electroconvulsive Therapy
(adverse effects)
- Male
- Plant Extracts
(therapeutic use)
- Psychotropic Drugs
(therapeutic use)
- Rats
- Rats, Wistar
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