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[A pharmacological study of the hepatoprotective activity of fructose-1,6-diphosphate].

Abstract
A fructose-1,6-diphosphate preparation was tested for hepatoprotective activity through biochemical and morphologic studies in experiments on Wistar rats sustaining D-galactosamine- and paracetamole-induced hepatotoxicity. Findings indicated the modeled hepatic lesions to be readily reproducible, to simulate some characteristics of human liver pathology, and to be suitable for testing substances expected to have hepatoprotective action; intraperitoneal administration of fructose-1,6-diphosphate at a dose of 1000 mg/kg body weight proved moderately protective against liver damage by D-galactosamine; the benefit observed concerned mostly dystrophic and inflammatory changes in the liver; in a number of cases, correlation was noted between biochemical serum parameters and pathomorphologic liver alterations.
AuthorsE Klouchek, M Markov, A Popov
JournalEksperimentalna meditsina i morfologiia (Eksp Med Morfol) Vol. 31 Issue 3-4 Pg. 60-71 ( 1993) ISSN: 0367-0643 [Print] Bulgaria
Vernacular TitleFarmakologichno prouchvane za khepatoprotektivna aktivnost na fruktozo-1,6-difosfat.
PMID7805621 (Publication Type: Comparative Study, English Abstract, Journal Article)
Chemical References
  • Fructosediphosphates
  • Immunologic Factors
  • Acetaminophen
  • Galactosamine
  • fructose-1,6-diphosphate
Topics
  • Acetaminophen (toxicity)
  • Animals
  • Dose-Response Relationship, Drug
  • Drug Interactions
  • Fructosediphosphates (pharmacology)
  • Galactosamine (toxicity)
  • Immunologic Factors (pharmacology)
  • Liver (drug effects, metabolism, pathology)
  • Male
  • Rats
  • Rats, Wistar

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