Evaluation of topical ibuprofen cream in the treatment of acute ankle sprains.

Abstract

One hundred patients who presented to the accident and emergency (A&E) department with an acute ankle sprain were entered into a study to determine the efficacy of topical ibuprofen cream by using a double-blind placebo controlled design in a single type of soft-tissue injury. The subjects were given either topical ibuprofen cream or a placebo cream in addition to the standard management of the department. Patients kept diaries recording walking ability and pain visual analogue scales for resting, standing and walking. A total of 51 patients returned diaries that were suitable for analysis. Patients using the topical ibuprofen cream had significant reduction in pain scores over the first 48 h of treatment.

• Authors: J Campbell, T Dunn
• Journal: Journal of accident & emergency medicine (J Accid Emerg Med) Vol. 11 Issue 3 Pg. 178-82 (Sep 1994) ISSN: 1351-0622 [Print] England
• PMID: 7804585 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Ointments
• Ibuprofen

Topics

• Administration, Topical
• Adolescent
• Adult
• Ankle Injuries (drug therapy)
• Double-Blind Method
• Emergency Service, Hospital
• Female
• Humans
• Ibuprofen (administration & dosage, therapeutic use)
• Male
• Middle Aged
• Ointments
• Pain (drug therapy)
• Pain Measurement
• Sprains and Strains (drug therapy)