Abstract |
Disease-free survival for patients with small sarcomas of bone has been impressively improved with the use of intensive combination chemotherapy and safe local control with surgery or radiation. The ability of monoclonal antibodies to recognize different antigens has allowed new insights into the histogenesis and has distinguished a neural variant now referred to as malignant peripheral neuroectodermal tumor. Both entities share the translocation t(11;22) (q24;q12) as a constant phenomenon. The breakpoint region has now been cloned, allowing for molecular identification and detection of tumor cells and opening a new era of diagnostic and staging possibilities. Patients with disseminated disease, either at diagnosis or in relapse, have benefitted from megatherapy regimens followed by bone marrow or peripheral stem cell rescue. However, this approach is still under investigation and remains to be standardized.
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Authors | H F Jürgens |
Journal | Current opinion in oncology
(Curr Opin Oncol)
Vol. 6
Issue 4
Pg. 391-6
(Jul 1994)
ISSN: 1040-8746 [Print] United States |
PMID | 7803540
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Chemical References |
- Biomarkers, Tumor
- Oncogene Proteins, Fusion
|
Topics |
- Adolescent
- Adult
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Biomarkers, Tumor
- Bone Neoplasms
(epidemiology, genetics, pathology, therapy)
- Cell Division
- Child
- Child, Preschool
- Chromosomes, Human, Pair 11
(ultrastructure)
- Chromosomes, Human, Pair 22
(ultrastructure)
- Clinical Trials as Topic
- Combined Modality Therapy
- Female
- Humans
- Incidence
- Male
- Neoplasm Metastasis
- Neuroectodermal Tumors, Primitive, Peripheral
(epidemiology, genetics, pathology, therapy)
- Oncogene Proteins, Fusion
(genetics)
- Radiotherapy
(methods)
- Sarcoma, Ewing
(epidemiology, genetics, pathology, therapy)
- Survival Rate
- Translocation, Genetic
- Treatment Outcome
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