Unusual mesenchymal and mixed tumors of the salivary gland. An immunohistochemical and flow cytometric analysis of three cases.

Abstract

Histological, immunohistochemical, and flow cytometric characteristics of three unusual parotid gland tumors are described. The patients were adult white men with carcinoma ex pleomorphic adenoma, true malignant mixed tumor, and primary parotid gland chondrosarcoma. The carcinoma ex pleomorphic adenoma showed evidence of simultaneous epithelial, myoepithelial, and mesenchymal differentiation by immunohistochemistry. The true malignant mixed tumor exhibited variable positivity for two keratins, vimentin, proliferating cell nuclear antigen, Ki67, and p53. The chondrosarcoma initially stained for vimentin, S100, muscle-specific actin, proliferating cell nuclear antigen, and Ki67, but it lost actin expression in its first recurrence, accompanied by more extensive Ki67 staining. DNA ploidy varied from diploid to aneuploid with intratumoral variation in the carcinosarcoma. S-phase fractions ranged from 2.43% to 13.9%. The findings underscore the diversity of tumors that may be pathogenetically related to, and at times derived from, pleomorphic adenoma.

• Authors: T Bocklage, R Feddersen
• Journal: Archives of pathology & laboratory medicine (Arch Pathol Lab Med) Vol. 119 Issue 1 Pg. 69-74 (Jan 1995) ISSN: 0003-9985 [Print] United States
• PMID: 7802557 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• DNA, Neoplasm

Topics

• Adenoma, Pleomorphic (genetics, pathology)
• Adult
• Aged
• Chondrosarcoma (pathology)
• DNA, Neoplasm (analysis)
• Flow Cytometry
• Humans
• Immunohistochemistry
• Male
• Mesenchymoma (genetics, pathology)
• Ploidies
• Salivary Gland Neoplasms (genetics, pathology)