Abstract |
The long-term antihypertensive efficacy of molsidomine 8 mg bid was studied in 24 patients with coronary artery disease in a double-blind, placebo-controlled trial of 3 weeks duration. Ambulatory 24-h blood pressure measurements were performed at days 1, 2, 7, 14, and 21. Sphygmomanometric measurements of blood pressure heart rate and a protocol for number and time of angina pectoris attacks were also taken. Following the application of molsidomine a reduction of mean 24-h systolic blood pressure of 14% and of mean diastolic blood pressure of 11% was observed. The duration of the blood-pressure-lowering action was 7 h. After 3 weeks of treatment with 8 mg molsidomine sr bid a persistent and significant reduction of systolic and diastolic blood pressure was found. A similar acute and long-term effect was found by manually measured blood pressures. Heart rate was unchanged under molsidomine while the frequency of angina pectoris was diminished. In conclusion, a long-lasting antihypertensive efficacy (without signs of tolerance) was found over a 3-week period of treatment with 8 mg molsidomine in a slow-release formulation given twice a day.
|
Authors | W A Fach, T Kostanecka, G Kober |
Journal | Zeitschrift fur Kardiologie
(Z Kardiol)
Vol. 83
Issue 9
Pg. 646-51
(Sep 1994)
ISSN: 0300-5860 [Print] Germany |
Vernacular Title | Antihypertensive Langzeitwirkung von retardiertem Molsidomin. |
PMID | 7801667
(Publication Type: Clinical Trial, English Abstract, Journal Article, Randomized Controlled Trial)
|
Chemical References |
- Delayed-Action Preparations
- Molsidomine
|
Topics |
- Blood Pressure
(drug effects)
- Blood Pressure Monitors
- Coronary Disease
(drug therapy)
- Delayed-Action Preparations
- Dose-Response Relationship, Drug
- Double-Blind Method
- Female
- Heart Rate
(drug effects)
- Humans
- Hypertension
(drug therapy)
- Long-Term Care
- Male
- Middle Aged
- Molsidomine
(administration & dosage, adverse effects)
|