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[Long-term antihypertensive effect of delayed-action molsidomine].

Abstract
The long-term antihypertensive efficacy of molsidomine 8 mg bid was studied in 24 patients with coronary artery disease in a double-blind, placebo-controlled trial of 3 weeks duration. Ambulatory 24-h blood pressure measurements were performed at days 1, 2, 7, 14, and 21. Sphygmomanometric measurements of blood pressure heart rate and a protocol for number and time of angina pectoris attacks were also taken. Following the application of molsidomine a reduction of mean 24-h systolic blood pressure of 14% and of mean diastolic blood pressure of 11% was observed. The duration of the blood-pressure-lowering action was 7 h. After 3 weeks of treatment with 8 mg molsidomine sr bid a persistent and significant reduction of systolic and diastolic blood pressure was found. A similar acute and long-term effect was found by manually measured blood pressures. Heart rate was unchanged under molsidomine while the frequency of angina pectoris was diminished. In conclusion, a long-lasting antihypertensive efficacy (without signs of tolerance) was found over a 3-week period of treatment with 8 mg molsidomine in a slow-release formulation given twice a day.
AuthorsW A Fach, T Kostanecka, G Kober
JournalZeitschrift fur Kardiologie (Z Kardiol) Vol. 83 Issue 9 Pg. 646-51 (Sep 1994) ISSN: 0300-5860 [Print] Germany
Vernacular TitleAntihypertensive Langzeitwirkung von retardiertem Molsidomin.
PMID7801667 (Publication Type: Clinical Trial, English Abstract, Journal Article, Randomized Controlled Trial)
Chemical References
  • Delayed-Action Preparations
  • Molsidomine
Topics
  • Blood Pressure (drug effects)
  • Blood Pressure Monitors
  • Coronary Disease (drug therapy)
  • Delayed-Action Preparations
  • Dose-Response Relationship, Drug
  • Double-Blind Method
  • Female
  • Heart Rate (drug effects)
  • Humans
  • Hypertension (drug therapy)
  • Long-Term Care
  • Male
  • Middle Aged
  • Molsidomine (administration & dosage, adverse effects)

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