Abstract |
The susceptibility to Leptospira interrogans serovar copenhageni in Mongolian gerbils treated with 10 micrograms of serum thymic factor (FTS) 1 day before infection was examined. Susceptibility of gerbils treated 5 times with 10 micrograms of FTS was also investigated. Mortality of FTS-treated gerbils was significantly lower than that of controls when small challenge doses were used. To analyse the FTS-induced resistance to leptospiral infection, natural killer (NK) cell activity and macrophage activity were studied. Macrophage activity was unaltered but NK cell activity was enhanced in FTS-treated gerbils, with or without leptospiral infection. Since no side-effects of FTS were observed, this compound should be considered for the treatment of leptospirosis.
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Authors | M Yukawa, K Mochizuki, T Kosaka, H Kamata, A Awaya, H Kobayashi, T Onodera |
Journal | Veterinary microbiology
(Vet Microbiol)
Vol. 41
Issue 1-2
Pg. 99-106
(Jul 1994)
ISSN: 0378-1135 [Print] Netherlands |
PMID | 7801529
(Publication Type: Journal Article)
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Chemical References |
- Thymic Factor, Circulating
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Topics |
- Animals
- Disease Models, Animal
- Gerbillinae
- Killer Cells, Natural
(immunology)
- Leptospira interrogans
(classification, immunology)
- Macrophages
(immunology)
- Male
- Serotyping
- Thymic Factor, Circulating
(administration & dosage, pharmacology)
- Weil Disease
(immunology, pathology, prevention & control)
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