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Liposomal doxorubicin in the treatment of AIDS-associated Kaposi's sarcoma: clinical, histological and cell biological evaluation.

Abstract
AIDS-associated Kaposi's sarcoma (KS) in eight patients was treated with the systemic application of liposomal doxorubicin (20 mg/m2 per cycle). After six cycles of treatment a significant regression of KS was observed in all patients. Tumour volume was reduced from 556 +/- 635 mm3 before therapy to 42 +/- 134 mm3 after therapy as determined by ultrasonography of selected tumours. Histological examination revealed a reduction of tumour-like structures and the absence of KS spindle cells in involved areas after therapy. In vitro experiments with KS-derived cell cultures, which most likely represent the KS spindle cells, suggested that liposomal doxorubicin may cause regression of KS via two different mechanisms: (i) by highly specific inhibition of KS spindle cell proliferation and (ii) by induction of monocyte chemoattractant protein-1 expression in KS spindle cells, which may result in increased recruitment of phagocytic cells (monocytes/macrophages) into the lesions. A cooperative action of both mechanisms may explain the high efficacy of liposomal doxorubicin in the treatment of AIDS-KS.
AuthorsM Stürzl, C Zietz, B Eisenburg, F D Goebel, R Gillitzer, P H Hofschneider, J R Bogner
JournalResearch in virology (Res Virol) 1994 May-Aug Vol. 145 Issue 3-4 Pg. 261-9 ISSN: 0923-2516 [Print] France
PMID7800953 (Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Liposomes
  • Pharmaceutical Vehicles
  • Doxorubicin
Topics
  • Acquired Immunodeficiency Syndrome (complications)
  • Adult
  • Cell Division (drug effects)
  • Doxorubicin (administration & dosage)
  • Fibroblasts (drug effects, pathology)
  • Gastrointestinal Neoplasms (drug therapy, etiology, pathology)
  • Humans
  • Liposomes
  • Lung Neoplasms (drug therapy, etiology, pathology)
  • Middle Aged
  • Mouth Neoplasms (drug therapy, etiology, pathology)
  • Pharmaceutical Vehicles
  • Sarcoma, Kaposi (drug therapy, etiology, pathology)
  • Tumor Cells, Cultured (drug effects, pathology)

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