Abstract | OBJECTIVES: BACKGROUND: METHODS:
Dobutamine stress echocardiography was performed in 102 consecutive patients with suspected or known coronary artery disease. Color flow Doppler was used to determine the presence and change in mitral regurgitation at baseline and peak dobutamine infusion (up to 40 micrograms/kg body weight per min). The mitral regurgitation color flow Doppler area was semiquantitatively graded as mild (< 4 cm2), moderate (4 to 8 cm2) or severe (> 8 cm2). Patients were assigned to ischemic and nonischemic groups according to the dobutamine stress echocardiographic results. RESULTS: The two groups achieved the same maximal dose and demonstrated similar blood pressure and heart rate responses to dobutamine infusion. Only two patients developed new mitral regurgitation during dobutamine infusion, and both had a normal dobutamine echocardiographic result. More patients without ischemia had no mitral regurgitation compared with patients with ischemia. There was an insufficient number of patients with coronary angiographic data to determine the effects of mitral regurgitation on the sensitivity and specificity of dobutamine stress echocardiography. Of 23 patients with a rest ejection fraction < 50%, 61% had an improvement in mitral regurgitation grade compared with 25% of patients with a rest ejection fraction > or = 50% (p < 0.02). CONCLUSIONS:
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Authors | S K Heinle, F D Tice, J Kisslo |
Journal | Journal of the American College of Cardiology
(J Am Coll Cardiol)
Vol. 25
Issue 1
Pg. 122-7
(Jan 1995)
ISSN: 0735-1097 [Print] United States |
PMID | 7798488
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Coronary Angiography
(statistics & numerical data)
- Dobutamine
(administration & dosage)
- Dose-Response Relationship, Drug
- Echocardiography
(drug effects, instrumentation, methods, statistics & numerical data)
- Female
- Hemodynamics
(drug effects)
- Humans
- Male
- Middle Aged
- Mitral Valve
(diagnostic imaging, drug effects)
- Mitral Valve Insufficiency
(diagnostic imaging, physiopathology)
- Ventricular Function, Left
(drug effects)
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