IgA antiphospholipid antibodies in HTLV-1-associated tropical spastic paraparesis.

Abstract

A retrovirus, human T cell lymphotropic virus type 1 (HTLV-1), is an essential but not a sufficient aetiologic factor for tropical spastic paraparesis (TSP). Because some TSP patients have biological false positive tests for treponemal infections (BFP-STS), we used ELISA to study BFP-STS and anticardiolipin antibodies in 42 Jamaican TSP patients. The data indicate that in TSP anticardiolipin antibodies occur in about 26% of patients, are associated with biological false positive treponemal serology, are relatively restricted to the IgA isotype and may be induced by HTLV-1 or other nontreponemal infections.

• Authors: W A Wilson, C Morgan Ost, E N Barton, M Smikle, B Hanchard, W A Blattner, S Doggett, A E Gharavi
• Journal: Lupus (Lupus) Vol. 4 Issue 2 Pg. 138-41 (Apr 1995) ISSN: 0961-2033 [Print] England
• PMID: 7795617 (Publication Type: Journal Article)

Chemical References

• Antibodies, Antiphospholipid
• Immunoglobulin A

Topics

• Adult
• Aged
• Antibodies, Antiphospholipid (blood)
• Female
• Humans
• Immunoglobulin A (blood)
• Male
• Middle Aged
• Paraparesis, Tropical Spastic (immunology)
• Treponemal Infections (diagnosis)