HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

[Essential thrombocythemia transformed to minimally differentiated acute myeloid leukemia].

Abstract
A 64-year-old female diagnosed for essential thrombocythemia was treated with MCNU 50 mg four times in the course of the disease. Six months after the last administration, in May 1991, she was admitted because of decreasing thrombocyte count and appearance of blasts in the peripheral blood. On admission, laboratory findings were as follows: WBC 700/microliters with 5% of blasts, RBC 331 x 10(4)/microliters, and PLT 17.9 x 10(4)/microliters. Bone marrow aspiration revealed hypocellular marrow with 39% blasts. About 5% of the blasts were positive for myeloperoxidase by electron microscopy analysis. Leukemic cells were positive for CD 7, 13, 33 and 34, negative for other lymphoid lineage markers, and demonstrated no rearrangement of TCR-beta, gamma and IgH genes. Although she was treated with low-dose cytosine arabinoside, no response was observed. Subdural hematoma and sequential pneumonia developed and the patient died eight months after leukemic transformation. In conclusion, we think that the leukemic transformation might have been developed in the natural course of essential thrombocythemia in the present case. However, we cannot exclude the influence of MCNU.
AuthorsE Ohtsuka, K Tezono, Y Saburi, H Kikuchi, M Nasu, J Satoh, K Taniguchi, T Nagano
JournalGan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 22 Issue 7 Pg. 941-4 (Jun 1995) ISSN: 0385-0684 [Print] Japan
PMID7794000 (Publication Type: Case Reports, English Abstract, Journal Article)
Chemical References
  • Nitrosourea Compounds
  • ranimustine
Topics
  • Cell Transformation, Neoplastic (pathology)
  • Female
  • Humans
  • Leukemia, Myeloid, Acute (pathology)
  • Middle Aged
  • Nitrosourea Compounds (therapeutic use)
  • Thrombocytosis (drug therapy, pathology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: