Abstract |
A 13 year old girl diagnosed as having chronic myeloid leukemia (CML) was treated with interferon-alpha (IFN-alpha) alone and 4 months later hematological remission was obtained. In the course of the IFN-alpha treatment there was neither infectious sign nor side effects. In this study we have examined the effect of IFN-alpha on superoxide O2- generation by polymorphonuclear neutrophils (PMN). The PMN of the patient generated less O2- than PMN from normal controls. When patient PMN were cultured in the presence of 1000 U/mL IFN-alpha, enhancement of the formyl- methionyl-leucyl-phenylalanine induced O2- generation following priming with tissue necrosis factor-alpha was observed. Over the course of the IFN-alpha therapy, such O2- generation was gradually restored. It is suggested that CML PMN are in the resting condition in terms of their ability to generate O2- and that IFN-alpha is effective in inducing O2- generation by CML PMN.
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Authors | T Tomoda, T Okada, H Hisakawa, H Wakiguchi, T Kurashige |
Journal | Acta paediatrica Japonica : Overseas edition
(Acta Paediatr Jpn)
Vol. 37
Issue 2
Pg. 217-21
(Apr 1995)
ISSN: 0374-5600 [Print] Australia |
PMID | 7793260
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Interferon-alpha
- Superoxides
- N-Formylmethionine Leucyl-Phenylalanine
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Topics |
- Adolescent
- Drug Synergism
- Female
- Humans
- Interferon-alpha
(therapeutic use)
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive
(blood, therapy)
- N-Formylmethionine Leucyl-Phenylalanine
(pharmacology)
- Neutrophils
(drug effects, metabolism)
- Superoxides
(blood)
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