Abstract | BACKGROUND: MATERIAL AND METHODS: Samples of a new bottled cysteamine 0.5% solution were analysed 1H-NMR-spectroscopically over a period of several weeks (AM 400/WB-NMR-instrument, Bruker/Karlsruhe; 400.15 MHz). Samples bottled in an argon atmosphere were compared to samples bottled without inert gas. Definite samples were opened four times a day (A). The remainder of the samples was stored closed (B). RESULTS: CONCLUSIONS: The preparation of cysteamine solution in an argon atmosphere is useful. One bottle can be used for about one week, if less than 10% of the oxidation product cystamine is accepted.
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Authors | M Gräf, H O Kalinowski |
Journal | Klinische Monatsblatter fur Augenheilkunde
(Klin Monbl Augenheilkd)
Vol. 206
Issue 4
Pg. 262-5
(Apr 1995)
ISSN: 0023-2165 [Print] Germany |
Vernacular Title | 1H-NMR-spektroskopische Untersuchung von Cysteamin-Augentropfen. |
PMID | 7791287
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Ophthalmic Solutions
- Cysteamine
- Cystamine
|
Topics |
- Cornea
(pathology)
- Corneal Diseases
(drug therapy, pathology)
- Cystamine
(analysis)
- Cysteamine
(administration & dosage, analysis)
- Cystinosis
(drug therapy, pathology)
- Dose-Response Relationship, Drug
- Drug Stability
- Humans
- Magnetic Resonance Spectroscopy
(methods)
- Ophthalmic Solutions
- Oxidation-Reduction
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