[Expression of Epstein-Barr virus encoded small RNA-1 and latent membrane protein-1 in midline T-cell lymphomas].

Abstract

Nine cases of midline T-cell lymphoma (MTL) were studied for expression of Epstein-Barr virus (EBV) encoded small RNA-1 (EBER-1) and EBV latent membrane protein-1 (LMP-1) using in situ hybridization and immunohistochemistry respectively. EBER-1 was detected in nuclei of tumor cells in 8/9 cases of MTL and LMP-1 was found on membrane and in cytoplasm of tumor cells in 7/9 cases of MTL. The results show: (1) There is a strong association between EBV and MTL. EBV may play an important role in the pathogenesis of MTL. (2) The detection frequency of EBV in MTL is higher than peripheral T-cell lymphoma from other sites of the body. (3) EBER-1 in situ hybridization and LMP-1 immunohistochemistry are sensitive and reliable in detection of EBV in MTL and the latter is more economic and convenient.

• Authors: X Zhou, Q Yan, X Zhang
• Journal: Zhonghua bing li xue za zhi = Chinese journal of pathology (Zhonghua Bing Li Xue Za Zhi) Vol. 24 Issue 2 Pg. 69-71 (Apr 1995) ISSN: 0529-5807 [Print] China
• PMID: 7788728 (Publication Type: English Abstract, Journal Article)

Chemical References

• EBV-associated membrane antigen, Epstein-Barr virus
• RNA, Viral
• Viral Matrix Proteins

Topics

• Herpesvirus 4, Human (genetics, isolation & purification)
• Humans
• Immunohistochemistry
• In Situ Hybridization
• Lymphoma, T-Cell (virology)
• RNA, Viral (analysis)
• Viral Matrix Proteins (analysis)