Vigabatrin monotherapy in resistant neonatal seizures.

Abstract

Seizures in a term infant with Ohtahara syndrome, associated with polymicrogyria, and a pre-term neonate with similar clinical features, failed to respond to conventional anticonvulsants, but were controlled with vigabatrin monotherapy. Another infant with Aicardi syndrome improved with vigabatrin. Autopsy in the first infant showed no evidence of intramyelinic oedema. The developmental outcome in the two survivors was better than expected for their condition.

• Authors: P S Baxter, D Gardner-Medwin, D D Barwick, P Ince, J Livingston, D Murdoch-Eaton
• Journal: Seizure (Seizure) Vol. 4 Issue 1 Pg. 57-9 (Mar 1995) ISSN: 1059-1311 [Print] England
• PMID: 7788110 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anticonvulsants
• gamma-Aminobutyric Acid
• Vigabatrin

Topics

• Agenesis of Corpus Callosum
• Anticonvulsants (administration & dosage, adverse effects)
• Atrophy
• Brain (abnormalities)
• Cerebral Cortex (abnormalities, pathology)
• Dose-Response Relationship, Drug
• Drug Administration Schedule
• Electroencephalography (drug effects)
• Female
• Humans
• Infant
• Infant, Newborn
• Infant, Premature, Diseases (diagnosis, drug therapy)
• Male
• Recurrence
• Spasms, Infantile (diagnosis, drug therapy)
• Syndrome
• Vigabatrin
• gamma-Aminobutyric Acid (administration & dosage, adverse effects, analogs & derivatives)