Abstract |
The effects of selenium and silver salts was studied by scanning ionic microscopy during experimental argyria mapping of the different basement membrane elements. The ionic microscope (IMS 4F) was equipped with a high resolution spectrometer giving high spatial resolution on the image obtained. After long-term treatment with silver salt alone, silver and sulphur deposits were observed in the membranes. After administration of selenium and silver salt, it was possible to map nitrogen, sulphur, selenium and silver to the glomerular basement membrane as well as to the wall of the kidney arterioles. In the latter, sulphur, selenium and silver were localized only in the elastic laminae of the walls. This process of precipitation of silver deposits in the membrane can be interpreted as process of selenium "detoxification" of the organism.
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Authors | J P Berry, R Dennebouy, M Chaintreau, F Dantin, G Slodzian, P Galle |
Journal | Cellular and molecular biology (Noisy-le-Grand, France)
(Cell Mol Biol (Noisy-le-grand))
Vol. 41
Issue 2
Pg. 265-70
(Mar 1995)
ISSN: 0145-5680 [Print] France |
PMID | 7787736
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Selenium Compounds
- Selenium Oxides
- Silver Nitrate
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Topics |
- Animals
- Arterioles
(drug effects, ultrastructure)
- Basement Membrane
(drug effects, ultrastructure)
- Drug Interactions
- Electron Probe Microanalysis
(methods)
- Kidney
(blood supply, drug effects, ultrastructure)
- Kidney Glomerulus
(blood supply, drug effects, ultrastructure)
- Male
- Rats
- Rats, Wistar
- Selenium Compounds
(pharmacology)
- Selenium Oxides
- Silver Nitrate
(pharmacology)
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