HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

[Effects of berberine on platelet aggregation and plasma levels of TXB2 and 6-keto-PGF1 alpha in rats with reversible middle cerebral artery occlusion].

Abstract
Berberine (Ber) 20 mg.kg-1.d-1 for 1, 3, or 5 d inhibited platelet aggregation induced by ADP, arachidonic acid (AA) and collagen (Coll) in rats with 24 h reversible middle cerebral artery occlusion (MCAO), and the platelet adhesiveness was inhibited as well. Using radioimmunoassay method, the thromboxane B2(TXB2) and 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha) contents in rat plasma were measured 24 h after MCAO. The results indicate that the TXB2 levels after drug treatment were lower than those in ischemia control rats, but the 6-keto-PGF1 alpha levels showed no obvious difference between the two groups. The same dose of Ber was also shown to inhibit thrombosis formation. This suggests that the decline of platelet aggregation and decrease of TXB2 content may be one of the important factors involved in the anti-cerebral ischemia effect of Ber.
AuthorsJ F Wu, T P Liu
JournalYao xue xue bao = Acta pharmaceutica Sinica (Yao Xue Xue Bao) Vol. 30 Issue 2 Pg. 98-102 ( 1995) ISSN: 0513-4870 [Print] China
PMID7785438 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Platelet Aggregation Inhibitors
  • Berberine
  • Thromboxane B2
  • 6-Ketoprostaglandin F1 alpha
  • Adenosine Diphosphate
Topics
  • 6-Ketoprostaglandin F1 alpha (blood)
  • Adenosine Diphosphate (pharmacology)
  • Animals
  • Berberine (pharmacology)
  • Brain Ischemia (blood)
  • Male
  • Platelet Adhesiveness (drug effects)
  • Platelet Aggregation (drug effects)
  • Platelet Aggregation Inhibitors (pharmacology)
  • Rats
  • Rats, Sprague-Dawley
  • Thromboxane B2 (blood)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: