[Examination by image analysis for determining quantitative DNA parameters of serous papillary adenocarcinoma of the endometrium--a single case analysis].

Abstract

Serous-papillary adenocarcinoma of the endometrium are rare tumors. We describe DNA-parameters of such a tumor. Imprint-cytologies were taken from 6 different tumor sites (myometrial invasion and 5 additional tumor localizations) and subjected to image-cytophotometry in order to determine their DNA-parameters. All histograms showed an aneuploid DNA-pattern. The DNA-malignancy grade (DNA-MG) was 2.21 +/- 0.11 on median and the 5c exceeding rate (5c ER) was 15.37 +/- 4.17 on median. These results and the slight variability of DNA-pattern at the reported serous-papillary adenocarcinoma support the hypothesis of an own entity of this tumor. Additionally, the high values of DNA-MG and 5c ER confirm the well known aggressive behavior of this tumor entity.

• Authors: U Köhler, L G Horn, G Naumann, H Nenning, K Bilek
• Journal: Zentralblatt fur Gynakologie (Zentralbl Gynakol) Vol. 117 Issue 4 Pg. 213-6 ( 1995) ISSN: 0044-4197 [Print] Germany
• Vernacular Title: Bildanalytische Untersuchungen zur Bestimmung quantitativer DNA-Parameter eines serös-papillären Adenokarzinoms des Endometrium--eine Einzelfallanalyse.
• PMID: 7778358 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• DNA, Neoplasm

Topics

• Aged
• Cystadenocarcinoma, Papillary (pathology, surgery)
• DNA, Neoplasm (analysis)
• Endometrial Neoplasms (pathology, surgery)
• Endometrium (pathology)
• Female
• Humans
• Hysterectomy
• Image Processing, Computer-Assisted (instrumentation)
• Neoplasm Invasiveness
• Neoplasm Staging