[Serial assessment of MIBG scintigraphy in a case of DCM with heart failure improved by beta-blocker therapy].

Abstract

We experienced a case of DCM (62-year-old man) improved by beta-blocker (Metoprolol) therapy and studied time course of MIBG scintigraphy. We measured cardiac functions by UCG and 99mTc cardiac pool imaging, and MIBG scintigraphy during 12 months of beta-blocker therapy. In planar images we measured washout rate (WR) in total myocardium and regional washout rate (rWR) in 6 segments of myocardium. Cardiac function improved after 3 months of therapy. The WR did not improve until 6 months, but improved after 9 months (Before: 35.1%, 3 months after: 34.6%, 6 months after: 33.6%, 9 months after: 27.6%, 12 months after: 25.4%). rWR in inferoapical segment first improved at 3 months (Before: 40.1%, 3 months after: 35.1%), whereas rWR in antero-apical segment improved after 6 months and that in anterior segment improved after 9 months. These results suggest that the improvement of cardiac sympathetic nerve function in DCM treated with beta-blocker was not identical in each myocardium region.

• Authors: K Yamamoto, S Asada, T Yabunouchi, R Morozumi, H Kusuoka, T Nishimura
• Journal: Kaku igaku. The Japanese journal of nuclear medicine (Kaku Igaku) Vol. 32 Issue 4 Pg. 413-8 (Apr 1995) ISSN: 0022-7854 [Print] Japan
• PMID: 7776548 (Publication Type: Case Reports, Journal Article)

Chemical References

• Iodine Radioisotopes
• Iodobenzenes
• 3-Iodobenzylguanidine
• Metoprolol

Topics

• 3-Iodobenzylguanidine
• Cardiomyopathy, Dilated (complications, diagnostic imaging, drug therapy)
• Follow-Up Studies
• Heart (diagnostic imaging)
• Heart Failure (complications, diagnostic imaging, drug therapy)
• Humans
• Iodine Radioisotopes
• Iodobenzenes
• Male
• Metoprolol (administration & dosage)
• Middle Aged
• Monitoring, Physiologic
• Radionuclide Imaging