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Susceptibility of Helicobacter pylori to antimicrobial agents: effect of sulglycotide.

Abstract
H. pylori is regarded as a primary etiologic factor in gastric disease and the therapies now include a combination of antimicrobial agents with antiulcer drugs. Here, the effect of a new gastroprotective agent, sulglycotide, on the in vitro anti-H. pylori activity of metronidazole, erythromycin, tetracycline, and amoxycillin was assessed. The assays in the absence of sulglycotide gave MIC value 0.10mg/L for erythromycin, 0.12mg/L for amoxycillin, 0.15mg/L for tetracycline and 14mg/L for metronidazole, while sulglycotide alone gave MIC value of 20mg/L. The sulglycotide at its optimal dose (5mg/L) evoked a 4-fold enhancement in the MIC of amoxycillin, 5-fold in tetracycline, and 8.3-fold in erythromycin, while the MIC of metronidazole improved 3.5-fold at 10mg/L sulglycotide. The results point towards the advantage of combination therapy of sulglycotide and antibiotics for H. pylori eradication.
AuthorsJ Piotrowski, V L Murty, A Slomiany, B L Slomiany
JournalBiochemistry and molecular biology international (Biochem Mol Biol Int) Vol. 35 Issue 3 Pg. 467-72 (Mar 1995) ISSN: 1039-9712 [Print] England
PMID7773183 (Publication Type: Journal Article)
Chemical References
  • Sialoglycoproteins
  • Metronidazole
  • sulglicotide
  • Erythromycin
  • Amoxicillin
  • Tetracycline
Topics
  • Amoxicillin (pharmacology)
  • Erythromycin (pharmacology)
  • Helicobacter pylori (drug effects)
  • Metronidazole (pharmacology)
  • Microbial Sensitivity Tests
  • Sialoglycoproteins (pharmacology)
  • Tetracycline (pharmacology)

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