Prophylactic effect of dietary zinc in a laboratory mouse model of swine dysentery.

Reduced prevalence of diarrhea and mortality has been reported after dietary supplementation with zinc compounds in swine with naturally acquired colibacillosis and those challenge-exposed with Serpulina hyodysenteriae; however, the usefulness of this approach for control of enteric diseases of swine remains to be determined. To examine the effect of dietary zinc-containing compounds on the colonization and development of cecal lesions associated with S hyodysenteriae infection, a defined diet alone or with added ZnO, ZnSO4, or Zn-methionine complex to a final concentration of approximately 6,000 mg of Zn2+/kg of complete feed was fed ad libitum to 156 female mice (strain C3H/HeN) for 10 days prior to oral inoculation either with S hyodysenteriae or sterile trypticase soy broth. Rations were continued for 42 days, while at weekly intervals, 3 mice/group were necropsied for determination of body weight, cecal weight, liver zinc concentration, presence of S hyodysenteriae in the cecum, and gross and histologic assessments of cecal lesions. From postinoculation day 0 to 42, the liver zinc concentration of mice fed the zinc-supplemented diets was approximately twice that of mice fed the basal diet, irrespective of the source of zinc. From postinoculation day 7 through 42, the overall recovery rate of S hyodysenteriae in infected mice fed the basal diet was 77.8%. In contrast, recovery rates of S hyodysenteriae from S hyodysenteriae-inoculated mice fed the zinc-supplemented diets were 0% for Zn-methionine and ZnO and 16.7% for ZnSO4. Mice fed the basal diet had significantly (P < 0.05) higher weight gain than mice fed the zinc-supplemented diets.(ABSTRACT TRUNCATED AT 250 WORDS)
AuthorsP Zhang, G E Duhamel, J V Mysore, M P Carlson, N R Schneider
JournalAmerican journal of veterinary research (Am J Vet Res) Vol. 56 Issue 3 Pg. 334-9 (Mar 1995) ISSN: 0002-9645 [Print] United States
PMID7771701 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
Chemical References
  • Zinc
  • Animal Feed
  • Animals
  • Brachyspira hyodysenteriae (drug effects)
  • Dysentery (microbiology, prevention & control, veterinary)
  • Female
  • Mice
  • Spirochaetales Infections (prevention & control, veterinary)
  • Swine
  • Swine Diseases (prevention & control)
  • Zinc (pharmacology)

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