Abstract | UNLABELLED: The aim of this study was to assess the potential role of 99mTc-tetrofosmin cardiac tomography in detecting totally occluded or severely stenosed coronary arteries. METHODS: Thirty-three patients (32 men, 1 woman; mean age, 52 +/- 9 yr) with chronic coronary artery disease (CAD) and left ventricular dysfunction (ejection fraction 40% +/- 12%) underwent resting 99mTc-tetrofosmin SPECT and coronary arteriography within 2 wk. Regional distribution of 99mTc-tetrofosmin activity was compared with the coronary anatomy. Tracer uptake was quantitatively analyzed in 22 segments for each patient. The activity in each segment was expressed as a percent of the peak activity. RESULTS: CONCLUSION: These results demonstrate that quantitative analysis of resting 99mTc-tetrofosmin regional uptake detects the majority of segments supplied by occluded coronary arteries with poor collateral flow and suggest that this tracer may be helpful in the diagnosis of acute myocardial infarction.
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Authors | A Cuocolo, A Soricelli, E Nicolai, F Squame, A Nappi, P Sullo, M Klain, S Cardei, M Salvatore |
Journal | Journal of nuclear medicine : official publication, Society of Nuclear Medicine
(J Nucl Med)
Vol. 36
Issue 6
Pg. 907-13
(Jun 1995)
ISSN: 0161-5505 [Print] United States |
PMID | 7769445
(Publication Type: Journal Article)
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Chemical References |
- Organophosphorus Compounds
- Organotechnetium Compounds
- technetium tc-99m tetrofosmin
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Topics |
- Adult
- Coronary Angiography
- Coronary Disease
(diagnostic imaging, pathology)
- Coronary Vessels
(pathology)
- Female
- Heart
(diagnostic imaging)
- Humans
- Male
- Middle Aged
- Myocardial Infarction
(diagnostic imaging)
- Organophosphorus Compounds
- Organotechnetium Compounds
- Tomography, Emission-Computed, Single-Photon
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