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Elevated cellular immune responses and interferon-gamma release after long-term diethylcarbamazine treatment of patients with human lymphatic filariasis.

Abstract
Cellular immune responses to filarial antigens were examined in persons before and 1 year after beginning treatment with diethylcarbamazine (DEC). The subjects (17 microfilaremics, 13 asymptomatic amicrofilaremics, and 13 with elephantiasis) had not responded to Brgia malayi adult worm antigen (BmA) before chemotherapy. T cell proliferative responses to BmA improved significantly after therapy in the 3 clinical groups (P < .05) but was highest in the elephantiasis patients and asymptomatic amicrofilareimics. Cytokine release profiles after stimulation with parasite antigen were analyzed. Production of interferon (IFN)-gamma by BmA-stimulated mononuclear cells increased significantly after DEC treatment (geometric mean, 39.6-55.7 U/mL; P < .05), largely due to improved responses in elephantiasis patients and asymptomatic amicrofilaremics. In contrast, BmA-induced interleukin (IL)-4 release did not change significantly in these same patients after treatment. Thus, both microfilaremic and amicrofilaremic infections with B. malayi are associated with similar down-regulation of proliferative T cell function and IFN-gamma release.
AuthorsE Sartono, Y C Kruize, A Kurniawan, P H van der Meide, F Partono, R M Maizels, M Yazdanbakhsh
JournalThe Journal of infectious diseases (J Infect Dis) Vol. 171 Issue 6 Pg. 1683-7 (Jun 1995) ISSN: 0022-1899 [Print] United States
PMID7769319 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antigens, Helminth
  • Tuberculin
  • Interferon-gamma
  • Diethylcarbamazine
Topics
  • Adolescent
  • Adult
  • Animals
  • Antigens, Helminth (immunology)
  • Brugia malayi (immunology)
  • Diethylcarbamazine (therapeutic use)
  • Drug Administration Schedule
  • Elephantiasis, Filarial (drug therapy)
  • Female
  • Humans
  • Immunity, Cellular
  • Interferon-gamma (metabolism)
  • Lymphocyte Activation
  • Male
  • T-Lymphocytes (immunology)
  • Tuberculin (immunology)

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