Antibiotic penetration of experimental intra-abdominal abscesses.

Abstract

Intra-abdominal abscess is seldom adequately treated by systemic antibiotics alone and often requires surgical or computed tomography-guided drainage for resolution. Abscess penetration of six currently used antibiotics was examined in a murine intra-abdominal abscess model. Ampicillin/sulbactam, cefmetazole, clindamycin, and trospectomycin penetrated intra-abdominal abscesses to a greater degree than cefoxitin and ceftriaxone. Abscess pus antibiotic levels were not significantly higher after multiple doses than after a single dose. Pus antibiotic levels below the MIC90 for Bacteroides and E. coli within intra-abdominal abscess were observed for most antibiotics with the doses used in this study. Selection of antibiotics with a greater ability to penetrate abscess may be important in optimally treating patients with abdominal infection.

• Authors: S Galandiuk, J Lamos, W Montgomery, S Young, H C Polk Jr
• Journal: The American surgeon (Am Surg) Vol. 61 Issue 6 Pg. 521-5 (Jun 1995) ISSN: 0003-1348 [Print] United States
• PMID: 7762902 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Bacterial Agents
• Cefmetazole
• Clindamycin
• trospectomycin
• Cefoxitin
• Ceftriaxone
• Ampicillin
• Spectinomycin
• Sulbactam

Topics

• Abdominal Abscess (blood, drug therapy)
• Ampicillin (pharmacokinetics, therapeutic use)
• Animals
• Anti-Bacterial Agents (blood, pharmacokinetics, therapeutic use)
• Bacteroides Infections (blood, drug therapy)
• Bacteroides fragilis
• Cefmetazole (pharmacokinetics, therapeutic use)
• Cefoxitin (pharmacokinetics, therapeutic use)
• Ceftriaxone (pharmacokinetics, therapeutic use)
• Clindamycin (pharmacokinetics, therapeutic use)
• Drug Evaluation, Preclinical
• Drug Therapy, Combination (pharmacokinetics, therapeutic use)
• Escherichia coli Infections (blood, drug therapy)
• Hydrogen-Ion Concentration
• Male
• Mice
• Microbial Sensitivity Tests
• Spectinomycin (analogs & derivatives, pharmacokinetics, therapeutic use)
• Sulbactam (pharmacokinetics, therapeutic use)