[Immunoscintigraphy of bone marrow in plasmacytoma].

Abstract

In 26 patients with plasmocytoma and 4 patients with benign monoclonal gammopathy bone marrow scintigraphy using 99mTc-labelled monoclonal antigranulocyte-antibodies was performed. Focal marrow defects were found in 18/26 patients with plasmocytoma but in none with benign monoclonal gammopathy. The results in plasmocytoma patients correlated well with the clinical staging system of Durie and Salmon. Quantification showed a suppressed bone marrow uptake ratio in 8/26 patients. A marked bone marrow expansion was present in only 2/26 patients. Bone marrow scintigraphy seems to be a valuable diagnostic tool in patients with plasmocytoma, especially as it is able to visualize the degree of bone marrow infiltration in a single protocol and so allows to follow up patients in a simple noninvasive manner.

• Authors: J Bathmann, W Brugger, C Ullrich, R Mertelsmann, E Moser
• Journal: Nuklearmedizin. Nuclear medicine (Nuklearmedizin) Vol. 34 Issue 2 Pg. 66-70 (Apr 1995) ISSN: 0029-5566 [Print] Germany
• Vernacular Title: Immunszintigraphie des Knochenmarks beim Plasmozytom.
• PMID: 7761276 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Antibodies, Monoclonal
• Technetium

Topics

• Antibodies, Monoclonal
• Bone Marrow (diagnostic imaging)
• Diagnosis, Differential
• Humans
• Neoplasm Staging
• Paraproteinemias (diagnostic imaging)
• Plasmacytoma (diagnostic imaging, pathology)
• Radioimmunodetection (methods)
• Technetium