[Changes in myocardial beta adrenergic receptors in left ventricular hypertrophy caused by barometric and volumetric overloads].

Abstract

While most prior studies examined late stages of heart failure, we determined initial changes of beta-adrenergic receptors (beta-AR) during left ventricular chronic volume and pressure overload. We investigated right auricular (RA) and left ventricular (LV) beta-AR density (Bmax, fmoles/mg protein) and beta 1-AR percentage in two groups of patients undergoing valve replacement without LV systolic dysfunction (LV ejection fraction > or = 60%), with normal plasma catecholamine levels and echocardiography LV hypertrophy. These results were compared with the values of a control group, composed by 8 patients with mitral stenosis and 5 cardiac transplant donors, and the values of 5 patients undergoing heart transplantation because of end-stage idiopathic dilated cardiomyopathy. These results show that, before alteration of LV systolic function occurs, left ventricular chronic overload induces a selective down-regulation of LV beta 1-AR compensated by an increase in beta 2-AR. These variations may be due to LV hypertrophy induced by volume or pressure overload.

• Authors: M Galinier, J M Senard, A Srour, V Ligou, P Valet, Y Glock, P Massabuau, D Roux, J L Montastruc, J P Bounhoure
• Journal: Archives des maladies du coeur et des vaisseaux (Arch Mal Coeur Vaiss) Vol. 87 Issue 8 Pg. 1015-8 (Aug 1994) ISSN: 0003-9683 [Print] France
• Vernacular Title: Modifications des récepteurs bêta-adrénergiques myocardiques au cours de l'hypertrophie ventriculaire gauche des surcharges barométriques et volumétriques.
• PMID: 7755450 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Catecholamines
• Receptors, Adrenergic, beta

Topics

• Catecholamines (blood)
• Down-Regulation
• Female
• Heart Valve Diseases (complications)
• Humans
• Hypertrophy, Left Ventricular (etiology, physiopathology)
• Male
• Middle Aged
• Myocardium (chemistry)
• Receptors, Adrenergic, beta (analysis, physiology)