A clinical trial of ipratropium bromide nasal spray in patients with perennial nonallergic rhinitis.
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| Abstract |
Intranasal ipratropium bromide has been shown to significantly reduce rhinorrhea. Use of a freon-propelled intranasal preparation has resulted in side effects associated with the drying properties of the propellant. The purpose of the present trial was to study the safety and efficacy of a new isotonic aqueous ipratropium bromide nasal spray pump, specifically in patients with perennial nonallergic rhinitis. Two hundred thirty-three patients participated in an 8-week double-blind parallel comparison of ipratropium bromide nasal spray with its vehicle, a saline solution. Treatment with the ipratropium spray resulted in a 30% reduction in rhinorrhea; this reduction was significantly greater than that seen with the saline vehicle. There was a modest reduction in postnasal drip, sneezing, and congestion with both treatments, which may be attributable to the salutary effects of the saline solution. Patients also perceived a significant reduction in the degree to which rhinorrhea interfered with their daily activities and moods. Treatment was well tolerated, with no drug-related systemic adverse events and no evidence of nasal rebound on discontinuation of treatment. Minor, infrequent episodes of nasal dryness and epistaxis were the only significant adverse events reported; these did not limit treatment.
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| Authors | E A Bronsky, H Druce, S R Findlay, F C Hampel, H Kaiser, P Ratner, M D Valentine, C C Wood |
| Journal | The Journal of allergy and clinical immunology (J Allergy Clin Immunol) Vol. 95 Issue 5 Pt 2 Pg. 1117-22 (May 1995) ISSN: 0091-6749 [Print] United States |
| PMID | 7751528 (Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial) |
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