Abstract | BACKGROUND: METHODS: RESULTS: Each of the 14 study patients who had hypersensitivity pneumonitis had work-related dyspnea and fever occurring several hours after the start of work with isocyanates. Typical clinical findings were the reduction of lung diffusing capacity (n = 10), reticular or nodular lung patterns in the x-ray film (n = 9), and serum IgG antibodies specific to isocyanate- human serum albumin conjugates (n = 10). Restrictive ventilation patterns in the inhalation challenge tests (n = 5), lymphocytic and/or neutrophilic alveolitis seen in bronchoalveolar lavage fluid analyses (n = 7), and lymphohistiocytic patterns mostly associated with mild fibrosis in lung histology (n = 5) confirmed the diagnosis. CONCLUSIONS:
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Authors | X Baur |
Journal | The Journal of allergy and clinical immunology
(J Allergy Clin Immunol)
Vol. 95
Issue 5 Pt 1
Pg. 1004-10
(May 1995)
ISSN: 0091-6749 [Print] United States |
PMID | 7751497
(Publication Type: Journal Article)
|
Chemical References |
- Allergens
- Immunoglobulin G
- Isocyanates
- 4,4'-diphenylmethane diisocyanate
|
Topics |
- Adolescent
- Adult
- Allergens
(adverse effects, immunology)
- Alveolitis, Extrinsic Allergic
(etiology)
- Antibody Specificity
- Biopsy
- Bronchoalveolar Lavage Fluid
(cytology)
- Bronchoscopy
- Chemical Industry
- Female
- Humans
- Immunoglobulin G
(blood, immunology)
- Isocyanates
(adverse effects, immunology)
- Lung
(pathology)
- Male
- Middle Aged
- Occupational Exposure
- Radiography, Thoracic
- Respiratory Mechanics
|