T/Tn pancarcinoma autoantigens: fundamental, diagnostic, and prognostic aspects.

Pathogenetic aspects of pancarcinoma T/Tn autoantigens were investigated; they are present in approximately 90% of all carcinomas from incipience and throughout. T/Tn are occluded in noncarcinoma (non-CA) diseased and healthy tissues. By serological and immunohistochemical methods, we found that well-differentiated carcinomata express a higher proportion of T than Tn, while in poorly differentiated carcinomata, Tn predominates over T. Tn density of primary carcinomas correlates positively with aggressiveness, early clinical relapse, and early death. Delayed-type skin hypersensitivity to T (DTHR-T) and solid-phase anti-T antibody immunoassay (SPIA-T), respectively, detected 85% of 461 and 88% of 222 carcinoma patients; < 7% of over 450 benign diseased and healthy subjects reacted positively in these assays. T/anti-T assays are highly effective in detecting incipient (TisN0M0 and T1N0M0) carcinomas: DTHR-T-85% of 41, and SPIA-T-96% of 26 patients. Positive anti-T tests predicted CA in 74% of 47 patients months to years before their biopsy/X-ray turned positive.
AuthorsG F Springer, P R Desai, M Ghazizadeh, H Tegtmeyer
JournalCancer detection and prevention (Cancer Detect Prev) Vol. 19 Issue 2 Pg. 173-82 ( 1995) ISSN: 0361-090X [Print] UNITED STATES
PMID7750105 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Antibodies
  • Antigens, Neoplasm
  • Antigens, Tumor-Associated, Carbohydrate
  • Autoantigens
  • Immunoglobulin M
  • Isoantigens
  • Thomsen-Friedenreich antibodies
  • Tn antigen
  • Thomsen-Friedenreich antigen
  • Adenocarcinoma (diagnosis, immunology)
  • Antibodies (blood)
  • Antigens, Neoplasm (analysis)
  • Antigens, Tumor-Associated, Carbohydrate (analysis)
  • Autoantigens (immunology)
  • Breast Neoplasms (diagnosis, immunology)
  • Carcinoma (diagnosis, immunology)
  • Carcinoma, Ductal, Breast (diagnosis, immunology)
  • Case-Control Studies
  • Cohort Studies
  • Humans
  • Immunoglobulin M (blood)
  • Isoantigens (immunology)
  • Prognosis

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