Abstract | OBJECTIVES: METHODS: RESULTS: More frequent N-9 use was not associated with genital ulcers and may have been protective against the lesions. Ulceration was not a strong risk factor for HIV acquisition in this study (odds ratio 1.1; 95% confidence interval 0.3-3.5). CONCLUSIONS: Frequent use of N-9 can cause genital irritation and ulceration. Ulcers, in turn, may be risk factors for HIV acquisition. This study, however, did not find an association between N-9 use and ulcers, nor between ulcers and HIV. There is probably a threshold of N-9 use frequency or dose below which the risk of ulceration is minimal. Ulcers due to infectious causes may have been prevented by N-9 use in this cohort.
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Authors | S S Weir, R E Roddy, L Zekeng, P J Feldblum |
Journal | Genitourinary medicine
(Genitourin Med)
Vol. 71
Issue 2
Pg. 78-81
(Apr 1995)
ISSN: 0266-4348 [Print] England |
PMID | 7744418
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- Contraceptive Agents, Female
- Suppositories
- Nonoxynol
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Topics |
- Adult
- Cameroon
(epidemiology)
- Case-Control Studies
- Cohort Studies
- Contraceptive Agents, Female
- Female
- Genital Diseases, Female
(chemically induced, epidemiology)
- HIV Seropositivity
(epidemiology)
- Humans
- Incidence
- Nonoxynol
(administration & dosage, adverse effects)
- Occupational Diseases
(epidemiology)
- Risk Factors
- Sex Work
- Suppositories
- Ulcer
(chemically induced, epidemiology)
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